This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison
Protein Domains
Figure 1
SMART and ProSite both identify the tudor domain as occuring in all homologs of the SMN1 gene.
Tudor Information(1):
The Tudor domain is a domain of around 50-70 amino acids which was first identified as a repeat present in 10 copies in Drosophila Tudor protein [1,2]. The Tudor domain is found in one or several copies in many eukaryotic proteins that colocalize with ribonucleoprotein or single-stranded DNA-associated complexes in the nucleus, in the mitochondrial membrane, or at kinetochores. The Tudor domain can be found in association with other domains, such as a staphylococcal nuclease (SN)-fold (see <PDOC00865>), a OTU domain (see <PDOC50802>), a KH domain (see <PDOC50084>), a DEAD/DEAH box helicase domain (see <PDOC00039>) or a coiled-coil domain. An insufficient amount of functional information concerning the proteins containing a Tudor domain is currently available from which to ascribe putative functions to Tudor domains. However, it is likely that Tudor domains function as protein-protein interaction motifs during RNA metabolism and/or transport and do not bind to RNA directly
Other species with proteins containing tudor domains(1):
Human
Rat
Drosophila
C.elegans
Rice
Published articles about the Tudor domain:
| sdarticle.pdf | |
| File Size: | 492 kb |
| File Type: | |
| nsb0101_27.pdf | |
| File Size: | 2570 kb |
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Reference:
1. Prosite (2001) Tudor Domain Profile. Retrieved Feb. 19 2009 from: http://www.expasy.ch/cgi-bin/nicedoc.pl?PS50304
2. (Figure 1) Huang, Y. et al. (2006) Science. 312(5774): 748-51. PDB: 2GFA
William Baader
[email protected]
Feb 25 2009
www.gen677.weebly.com
